Researchers at IIT-BHU have developed a novel treatment for gastro-duodenal ulcers and successfully tested

Varanasi 23 august:-(desk) Researchers at IIT-BHU, led by Professor Sairam Krishnamurthy, have developed a bioactive glass formulation containing barium oxide for treating gastro-duodenal ulcers

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Researchers in the Pharmaceutical Engineering department at IIT-BHU have made a significant breakthrough in the treatment of gastro-duodenal ulcers. Professor Sairam Krishnamurthy and research student Pankaj Paliwal's team developed an oral bioactive glass formulation that includes micronized barium oxide (BaBG).

This formulation exhibits protective and therapeutic effects against gastric and duodenal ulcers. It helps neutralize stomach acid, thereby reducing the severity of the ulcers.

The BaBG treatment promoted cell proliferation, aiding in the healing of ulcers. Additionally, this formulation creates a protective barrier that shields against harmful factors that exacerbate ulcers.

Professor Sairam Krishnamurthy stated that the lifetime prevalence rate of peptic ulcers in India is 11.22%, while the prevalence rate of duodenal ulcers worldwide is approximately 3.00%. These ulcers are more common in men and are

typically caused by factors such as H. pylori infection, the use of non-steroidal anti-inflammatory drugs (NSAIDs), smoking, daily aspirin consumption, and gastrointestinal cancer. In these ulcers, the stomach's acidic protective mechanisms are weakened, leading to the development of ulcerative

He explained that until now, proton pump inhibitors (PPIs) and histamine type 2 receptor blockers have been used to reduce gastric acid production and heal ulcers. However, long-term use of these medications can be associated with side effects. Therefore, there is a need for a safer and more effective anti-ulcer agent. He conducted this research on mice.